Index: b/Lib/sysconfig.py
===================================================================
--- a/Lib/sysconfig.py
+++ b/Lib/sysconfig.py
@@ -337,6 +337,8 @@ def get_makefile_filename():
         config_dir_name = 'config-%s%s' % (_PY_VERSION_SHORT, sys.abiflags)
     else:
         config_dir_name = 'config'
+    if hasattr(sys.implementation, '_multiarch'):
+        config_dir_name += '-%s' % sys.implementation._multiarch
     return os.path.join(get_path('stdlib'), config_dir_name, 'Makefile')
 
 def _generate_posix_vars():
@@ -543,6 +545,12 @@ def get_config_vars(*args):
         # the init-function.
         _CONFIG_VARS['userbase'] = _getuserbase()
 
+        multiarch = get_config_var('MULTIARCH')
+        if multiarch:
+            _CONFIG_VARS['multiarchsubdir'] = '/' + multiarch
+        else:
+            _CONFIG_VARS['multiarchsubdir'] = ''
+
         # Always convert srcdir to an absolute path
         srcdir = _CONFIG_VARS.get('srcdir', _PROJECT_BASE)
         if os.name == 'posix':
Index: b/Lib/distutils/sysconfig.py
===================================================================
--- a/Lib/distutils/sysconfig.py
+++ b/Lib/distutils/sysconfig.py
@@ -99,6 +99,9 @@ def get_python_inc(plat_specific=0, pref
                 incdir = os.path.join(get_config_var('srcdir'), 'Include')
                 return os.path.normpath(incdir)
         python_dir = 'python' + get_python_version() + build_flags
+        if not python_build and plat_specific:
+            import sysconfig
+            return sysconfig.get_path('platinclude')
         return os.path.join(prefix, "include", python_dir)
     elif os.name == "nt":
         return os.path.join(prefix, "include")
@@ -257,6 +260,8 @@ def get_makefile_filename():
         return os.path.join(_sys_home or project_base, "Makefile")
     lib_dir = get_python_lib(plat_specific=0, standard_lib=1)
     config_file = 'config-{}{}'.format(get_python_version(), build_flags)
+    if hasattr(sys.implementation, '_multiarch'):
+        config_file += '-%s' % sys.implementation._multiarch
     return os.path.join(lib_dir, config_file, 'Makefile')
 
 
Index: b/Makefile.pre.in
===================================================================
--- a/Makefile.pre.in
+++ b/Makefile.pre.in
@@ -759,6 +759,7 @@ Modules/signalmodule.o: $(srcdir)/Module
 
 Python/dynload_shlib.o: $(srcdir)/Python/dynload_shlib.c Makefile
 	$(CC) -c $(PY_CORE_CFLAGS) \
+		$(if $(MULTIARCH),-DMULTIARCH='"$(MULTIARCH)"') \
 		-DSOABI='"$(SOABI)"' \
 		-o $@ $(srcdir)/Python/dynload_shlib.c
 
@@ -770,6 +771,7 @@ Python/dynload_hpux.o: $(srcdir)/Python/
 Python/sysmodule.o: $(srcdir)/Python/sysmodule.c Makefile
 	$(CC) -c $(PY_CORE_CFLAGS) \
 		-DABIFLAGS='"$(ABIFLAGS)"' \
+		-DMULTIARCH='"$(MULTIARCH)"' \
 		-o $@ $(srcdir)/Python/sysmodule.c
 
 $(IO_OBJS): $(IO_H)
@@ -1336,6 +1338,10 @@ libinstall:	build_all $(srcdir)/Lib/$(PL
 $(srcdir)/Lib/$(PLATDIR):
 	mkdir $(srcdir)/Lib/$(PLATDIR)
 	cp $(srcdir)/Lib/plat-generic/regen $(srcdir)/Lib/$(PLATDIR)/regen
+	if [ -n "$(MULTIARCH)" ]; then \
+	  cp -p $(srcdir)/Lib/plat-linux/*.py $(srcdir)/Lib/$(PLATDIR)/.; \
+	  rm -f $(srcdir)/Lib/$(PLATDIR)/IN.py; \
+	fi
 	export PATH; PATH="`pwd`:$$PATH"; \
 	export PYTHONPATH; PYTHONPATH="`pwd`/Lib"; \
 	export DYLD_FRAMEWORK_PATH; DYLD_FRAMEWORK_PATH="`pwd`"; \
@@ -1386,7 +1392,7 @@ inclinstall:
 LIBPL=		@LIBPL@
 
 # pkgconfig directory
-LIBPC=		$(LIBDIR)/pkgconfig
+LIBPC=		$(LIBDIR)/$(MULTIARCH)/pkgconfig
 
 libainstall:	@DEF_MAKE_RULE@ python-config
 	@for i in $(LIBDIR) $(LIBPL) $(LIBPC); \
Index: b/Python/sysmodule.c
===================================================================
--- a/Python/sysmodule.c
+++ b/Python/sysmodule.c
@@ -1733,6 +1733,15 @@ make_impl_info(PyObject *version_info)
     if (res < 0)
         goto error;
 
+    /* For Debian multiarch support. */
+    value = PyUnicode_FromString(MULTIARCH);
+    if (value == NULL)
+        goto error;
+    res = PyDict_SetItemString(impl_info, "_multiarch", value);
+    Py_DECREF(value);
+    if (res < 0)
+        goto error;
+
     /* dict ready */
 
     ns = _PyNamespace_New(impl_info);
Index: b/configure.ac
===================================================================
--- a/configure.ac
+++ b/configure.ac
@@ -874,7 +874,12 @@ if test x$PLATFORM_TRIPLET != x && test
     AC_MSG_ERROR([internal configure error for the platform triplet, please file a bug report])
   fi
 fi
-PLATDIR=plat-$MACHDEP
+
+if test x$PLATFORM_TRIPLET = x; then
+  PLATDIR=plat-$MACHDEP
+else
+  PLATDIR=plat-$PLATFORM_TRIPLET
+fi
 AC_SUBST(PLATDIR)
 AC_SUBST(PLATFORM_TRIPLET)
 
@@ -4550,7 +4555,7 @@ AC_MSG_RESULT($LDVERSION)
 
 dnl define LIBPL after ABIFLAGS and LDVERSION is defined.
 AC_SUBST(PY_ENABLE_SHARED)
-LIBPL='$(prefix)'"/lib/python${VERSION}/config-${LDVERSION}"
+LIBPL='${prefix}'"/lib/python${VERSION}/config-${LDVERSION}-${MULTIARCH}"
 AC_SUBST(LIBPL)
 
 # Check whether right shifting a negative integer extends the sign bit