--- a/Lib/_osx_support.py
+++ b/Lib/_osx_support.py
@@ -17,7 +17,7 @@ __all__ = [
 _UNIVERSAL_CONFIG_VARS = ('CFLAGS', 'LDFLAGS', 'CPPFLAGS', 'BASECFLAGS',
                             'BLDSHARED', 'LDSHARED', 'CC', 'CXX',
                             'PY_CFLAGS', 'PY_LDFLAGS', 'PY_CPPFLAGS',
-                            'PY_CORE_CFLAGS', 'PY_CORE_LDFLAGS')
+                            'PY_CORE_CFLAGS')
 
 # configuration variables that may contain compiler calls
 _COMPILER_CONFIG_VARS = ('BLDSHARED', 'LDSHARED', 'CC', 'CXX')
--- a/Lib/test/pythoninfo.py
+++ b/Lib/test/pythoninfo.py
@@ -420,10 +420,7 @@ def collect_sysconfig(info_add):
         'OPT',
         'PY_CFLAGS',
         'PY_CFLAGS_NODIST',
-        'PY_CORE_LDFLAGS',
         'PY_LDFLAGS',
-        'PY_LDFLAGS_NODIST',
-        'PY_STDMODULE_CFLAGS',
         'Py_DEBUG',
         'Py_ENABLE_SHARED',
         'SHELL',
--- a/Lib/test/test__osx_support.py
+++ b/Lib/test/test__osx_support.py
@@ -24,7 +24,7 @@ class Test_OSXSupport(unittest.TestCase)
         for cv in ('CFLAGS', 'LDFLAGS', 'CPPFLAGS',
                             'BASECFLAGS', 'BLDSHARED', 'LDSHARED', 'CC',
                             'CXX', 'PY_CFLAGS', 'PY_LDFLAGS', 'PY_CPPFLAGS',
-                            'PY_CORE_CFLAGS', 'PY_CORE_LDFLAGS'):
+                            'PY_CORE_CFLAGS'):
             if cv in self.env:
                 self.env.unset(cv)
 
--- a/Makefile.pre.in
+++ b/Makefile.pre.in
@@ -85,10 +85,6 @@ CONFIGURE_CFLAGS=	@CFLAGS@
 # Use it when a compiler flag should _not_ be part of the distutils CFLAGS
 # once Python is installed (Issue #21121).
 CONFIGURE_CFLAGS_NODIST=@CFLAGS_NODIST@
-# LDFLAGS_NODIST is used in the same manner as CFLAGS_NODIST.
-# Use it when a linker flag should _not_ be part of the distutils LDFLAGS
-# once Python is installed (bpo-35257)
-CONFIGURE_LDFLAGS_NODIST=@LDFLAGS_NODIST@
 CONFIGURE_CPPFLAGS=	@CPPFLAGS@
 CONFIGURE_LDFLAGS=	@LDFLAGS@
 # Avoid assigning CFLAGS, LDFLAGS, etc. so users can use them on the
@@ -101,7 +97,6 @@ PY_CFLAGS_NODIST=$(CONFIGURE_CFLAGS_NODI
 # environment variables
 PY_CPPFLAGS=	$(BASECPPFLAGS) -I. -I$(srcdir)/Include $(CONFIGURE_CPPFLAGS) $(CPPFLAGS)
 PY_LDFLAGS=	$(CONFIGURE_LDFLAGS) $(LDFLAGS)
-PY_LDFLAGS_NODIST=$(CONFIGURE_LDFLAGS_NODIST) $(LDFLAGS_NODIST)
 NO_AS_NEEDED=	@NO_AS_NEEDED@
 LDLAST=		@LDLAST@
 SGI_ABI=	@SGI_ABI@
@@ -116,8 +111,6 @@ CFLAGSFORSHARED=@CFLAGSFORSHARED@
 PY_STDMODULE_CFLAGS= $(PY_CFLAGS) $(PY_CFLAGS_NODIST) $(PY_CPPFLAGS) $(CFLAGSFORSHARED)
 PY_BUILTIN_MODULE_CFLAGS= $(PY_STDMODULE_CFLAGS) -DPy_BUILD_CORE_BUILTIN
 PY_CORE_CFLAGS=	$(PY_STDMODULE_CFLAGS) -DPy_BUILD_CORE
-# Linker flags used for building the interpreter object files
-PY_CORE_LDFLAGS=$(PY_LDFLAGS) $(PY_LDFLAGS_NODIST)
 # Strict or non-strict aliasing flags used to compile dtoa.c, see above
 CFLAGS_ALIASING=@CFLAGS_ALIASING@
 
@@ -157,7 +150,7 @@ CONFINCLUDEPY=	$(CONFINCLUDEDIR)/python$
 SHLIB_SUFFIX=	@SHLIB_SUFFIX@
 EXT_SUFFIX=	@EXT_SUFFIX@
 LDSHARED=	@LDSHARED@ $(PY_LDFLAGS)
-BLDSHARED=	@BLDSHARED@ $(PY_CORE_LDFLAGS)
+BLDSHARED=	@BLDSHARED@ $(PY_LDFLAGS)
 LDCXXSHARED=	@LDCXXSHARED@
 DESTSHARED=	$(BINLIBDEST)/lib-dynload
 
@@ -506,7 +499,7 @@ profile-run-stamp:
 	touch $@
 
 build_all_generate_profile:
-	$(MAKE) @DEF_MAKE_RULE@ CFLAGS_NODIST="$(CFLAGS_NODIST) $(PGO_PROF_GEN_FLAG)" LDFLAGS_NODIST="$(LDFLAGS_NODIST) $(PGO_PROF_GEN_FLAG)" LIBS="$(LIBS)"
+	$(MAKE) @DEF_MAKE_RULE@ CFLAGS_NODIST="$(CFLAGS) $(PGO_PROF_GEN_FLAG)" LDFLAGS="$(LDFLAGS) $(PGO_PROF_GEN_FLAG)" LIBS="$(LIBS)"
 
 run_profile_task:
 	@ # FIXME: can't run for a cross build
@@ -520,7 +513,7 @@ build_all_merge_profile:
 profile-opt: profile-run-stamp
 	@echo "Rebuilding with profile guided optimizations:"
 	-rm -f profile-clean-stamp
-	$(MAKE) @DEF_MAKE_RULE@ CFLAGS_NODIST="$(CFLAGS_NODIST) $(PGO_PROF_USE_FLAG)" LDFLAGS_NODIST="$(LDFLAGS_NODIST)"
+	$(MAKE) @DEF_MAKE_RULE@ CFLAGS_NODIST="$(CFLAGS) $(PGO_PROF_USE_FLAG)" LDFLAGS="$(LDFLAGS)"
 
 # Compile and run with gcov
 .PHONY=coverage coverage-lcov coverage-report
@@ -577,7 +570,7 @@ clinic: check-clean-src $(srcdir)/Module
 
 # Build the interpreter
 $(BUILDPYTHON):	Programs/python.o $(LIBRARY) $(LDLIBRARY) $(PY3LIBRARY)
-	$(LINKCC) $(PY_CORE_LDFLAGS) $(LINKFORSHARED) -o $@ Programs/python.o $(BLDLIBRARY) $(LIBS) $(MODLIBS) $(SYSLIBS) $(LDLAST)
+	$(LINKCC) $(PY_LDFLAGS) $(LINKFORSHARED) -o $@ Programs/python.o $(BLDLIBRARY) $(LIBS) $(MODLIBS) $(SYSLIBS) $(LDLAST)
 
 platform: $(BUILDPYTHON) pybuilddir.txt
 	$(RUNSHARED) $(PYTHON_FOR_BUILD) -c 'import sys ; from sysconfig import get_platform ; print("%s-%d.%d" % (get_platform(), *sys.version_info[:2]))' >platform
@@ -642,7 +635,7 @@ libpython3.so:	libpython$(LDVERSION).so
 	$(BLDSHARED) $(NO_AS_NEEDED) -o $@ -Wl,-h$@ $^
 
 libpython$(LDVERSION).dylib: $(LIBRARY_OBJS)
-	 $(CC) -dynamiclib -Wl,-single_module $(PY_CORE_LDFLAGS) -undefined dynamic_lookup -Wl,-install_name,$(prefix)/lib/libpython$(LDVERSION).dylib -Wl,-compatibility_version,$(VERSION) -Wl,-current_version,$(VERSION) -o $@ $(LIBRARY_OBJS) $(SHLIBS) $(LIBC) $(LIBM) $(LDLAST); \
+	 $(CC) -dynamiclib -Wl,-single_module $(PY_LDFLAGS) -undefined dynamic_lookup -Wl,-install_name,$(prefix)/lib/libpython$(LDVERSION).dylib -Wl,-compatibility_version,$(VERSION) -Wl,-current_version,$(VERSION) -o $@ $(LIBRARY_OBJS) $(SHLIBS) $(LIBC) $(LIBM) $(LDLAST); \
 
 
 libpython$(VERSION).sl: $(LIBRARY_OBJS)
@@ -667,7 +660,7 @@ $(PYTHONFRAMEWORKDIR)/Versions/$(VERSION
 		$(LIBRARY) \
 		$(RESSRCDIR)/Info.plist
 	$(INSTALL) -d -m $(DIRMODE) $(PYTHONFRAMEWORKDIR)/Versions/$(VERSION)
-	$(CC) -o $(LDLIBRARY) $(PY_CORE_LDFLAGS) -dynamiclib \
+	$(CC) -o $(LDLIBRARY) $(PY_LDFLAGS) -dynamiclib \
 		-all_load $(LIBRARY) -Wl,-single_module \
 		-install_name $(DESTDIR)$(PYTHONFRAMEWORKINSTALLDIR)/Versions/$(VERSION)/$(PYTHONFRAMEWORK) \
 		-compatibility_version $(VERSION) \
@@ -718,7 +711,7 @@ Modules/Setup: $(srcdir)/Modules/Setup.d
 	fi
 
 Programs/_testembed: Programs/_testembed.o $(LIBRARY) $(LDLIBRARY) $(PY3LIBRARY)
-	$(LINKCC) $(PY_CORE_LDFLAGS) $(LINKFORSHARED) -o $@ Programs/_testembed.o $(BLDLIBRARY) $(LIBS) $(MODLIBS) $(SYSLIBS) $(LDLAST)
+	$(LINKCC) $(PY_LDFLAGS) $(LINKFORSHARED) -o $@ Programs/_testembed.o $(BLDLIBRARY) $(LIBS) $(MODLIBS) $(SYSLIBS) $(LDLAST)
 
 ############################################################################
 # Importlib
@@ -726,7 +719,7 @@ Programs/_testembed: Programs/_testembed
 Programs/_freeze_importlib.o: Programs/_freeze_importlib.c Makefile
 
 Programs/_freeze_importlib: Programs/_freeze_importlib.o $(LIBRARY_OBJS_OMIT_FROZEN)
-	$(LINKCC) $(PY_CORE_LDFLAGS) -o $@ Programs/_freeze_importlib.o $(LIBRARY_OBJS_OMIT_FROZEN) $(LIBS) $(MODLIBS) $(SYSLIBS) $(LDLAST)
+	$(LINKCC) $(PY_LDFLAGS) -o $@ Programs/_freeze_importlib.o $(LIBRARY_OBJS_OMIT_FROZEN) $(LIBS) $(MODLIBS) $(SYSLIBS) $(LDLAST)
 
 .PHONY: regen-importlib
 regen-importlib: Programs/_freeze_importlib
@@ -808,7 +801,7 @@ Python/sysmodule.o: $(srcdir)/Python/sys
 $(IO_OBJS): $(IO_H)
 
 $(PGEN): $(PGENOBJS)
-		$(CC) $(OPT) $(PY_CORE_LDFLAGS) $(PGENOBJS) $(LIBS) -o $(PGEN)
+		$(CC) $(OPT) $(PY_LDFLAGS) $(PGENOBJS) $(LIBS) -o $(PGEN)
 
 .PHONY: regen-grammar
 regen-grammar: $(PGEN)
--- a/configure.ac
+++ b/configure.ac
@@ -1395,7 +1395,7 @@ if test "$Py_LTO" = 'true' ; then
   fi
 
   CFLAGS_NODIST="$CFLAGS_NODIST $LTOFLAGS"
-  LDFLAGS_NODIST="$LDFLAGS_NODIST $LTOFLAGS"
+  LDFLAGS="$LDFLAGS $LTOFLAGS"
 fi
 
 # Enable PGO flags.
@@ -1555,7 +1555,6 @@ fi
 
 AC_SUBST(BASECFLAGS)
 AC_SUBST(CFLAGS_NODIST)
-AC_SUBST(LDFLAGS_NODIST)
 
 # The -arch flags for universal builds on OSX
 UNIVERSAL_ARCH_FLAGS=
--- a/setup.py
+++ b/setup.py
@@ -18,16 +18,11 @@ from distutils.spawn import find_executa
 
 cross_compiling = "_PYTHON_HOST_PLATFORM" in os.environ
 
-# Set common compiler and linker flags derived from the Makefile,
-# reserved for building the interpreter and the stdlib modules.
-# See bpo-21121 and bpo-35257
-def set_compiler_flags(compiler_flags, compiler_py_flags_nodist):
-    flags = sysconfig.get_config_var(compiler_flags)
-    py_flags_nodist = sysconfig.get_config_var(compiler_py_flags_nodist)
-    sysconfig.get_config_vars()[compiler_flags] = flags + ' ' + py_flags_nodist
-
-set_compiler_flags('CFLAGS', 'PY_CFLAGS_NODIST')
-set_compiler_flags('LDFLAGS', 'PY_LDFLAGS_NODIST')
+# Add special CFLAGS reserved for building the interpreter and the stdlib
+# modules (Issue #21121).
+cflags = sysconfig.get_config_var('CFLAGS')
+py_cflags_nodist = sysconfig.get_config_var('PY_CFLAGS_NODIST')
+sysconfig.get_config_vars()['CFLAGS'] = cflags + ' ' + py_cflags_nodist
 
 class Dummy:
     """Hack for parallel build"""